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PROPRIETARY NAME & SIZES

F1OCL VETERINARY DISINFECTANT
(liquid, dilute as directed 5L, 1L RTU)
(Reg. No. G3076, Act 36/1947) (Reg. No. Act 29 GNR 529/29990/040/150)

F1OCLXD VETERINARY DISINFECTANT/CLEANSER
(liquid, dilute as directed 5L)

(Reg. No. G3077, Act 36/1947) (Reg. No. Act 29 GNR 529/29990/040/150)

F10 SKIN PREP SOLUTION
(liquid, use as is, in 5L)
(Reg No G 3105, Act 36/1947)

F10 ODOUR ELIMINATOR
(liquid, use as is in 250ml and 500ml , dilute as directed in the 5 L)
(Reg No Act 29 GNR 529/29990/040/150)

F10 DISINFECTANT AEROSOL & AEROSOL FOGGER
(500ml aerosol pressurised dispensing canister, use as is)
(Reg No Act 29 GNR 529/29990/040/150)

F10 INSECTICIDE SURFACE SPRAY
(liquid, use as is, in 500m1)
(Reg. No. HSE No. 9362)

F10 WIPES
(100 impregnated cellulose tissues)
(Reg No Act 29 GNR 529/29990/040/150)

COMPOSITION
The core actives of all the disinfectant products are quaternary ammonium and biguanide compound, with non toxic ampholytic surfactants and sequesterants.

LEVEL OF ACTIVES OTHER pH*
F1OCL VETERINARY DISINFECTANT
QAC and biguanide 1,16% Ampholytic surfactants and sequesterants
Water to balance
7.5
F10 DISINFECTANT RTU
QAC and blguanidine 0.02% Ampholytic surfactants, sequesterants/detergents Fragrance
Water to balance
7.5
F1OCLXD VETERINARY DISINFECTANT/CLEANSER
QAC and biguanide 1,16% Ampholytic surfactants, sequesterants/detergents
Fragrance
Water to balance
7.5
F10 SKIN PREP SOLUTION
QAC and biguanide 0,05% Ampholytic surfactants and sequesterants
Alcohol 20%
Water to balance
6.5
F10 ODOUR ELIMINATOR
QAC and biguanide 0,12% Ampholytic surfactants and sequesterants
Fragrance
Water to balance
5.9
F10 AEROSOL DISINFECTANT
QAC and biguanide 0,072% Ampholytic surfactants and sequesterants propellant 7.5
F10 INSECTICIDE SURFACE SPRAY FOR ANIMAL HOUSING
QAC and biguanide 0,116%
Cypermethrin 0,25%
Ampholytic surfactants and sequesterants 7.5
F10 WIPES AND SACHETS
QAC and biguanide 0,05% Ampholytic surfactants and sequesterants 7.5

* The pH value refers to the packed concentration

INDICATIONS

A broad spectrum biocide effective against bacteria, fungi, viruses and bacterial and fungal spores is indicative of those shown below:-

BACTERIA
(gram positive and
gram negative (spp)
FUNGI,
YEASTS and
MOULDS (spp)
VIRUSES
(enveloped and
non-enveloped)
SPORES
(bacterial and
fungal) spp
Acinetobacter Listeria Aspergillus Adenovirus Aspergillus
Campylobacter MRSA Candida Avian Influenza
H5N2 HPA1
Bacillus
Chlamydophila Mycobacterium Microsporum Canineparvovirus Microsporum
Clostridium Mycoplasma Penicillium Circovirus Penicillium
Cholera Micrococcus Trichophyton Enterovirus Trichophyton
Corynebacterium Ornitobacteriun
Rhinotracheale
Foot and Mouth Disease
Citrobacter Pasteurella Feline Herpesvirus
Entercoccus Proteus vulgaris Hepatitis B
Enterobacter Pseudomonas HIV
Escherichia coli Salmonella IBD
Klebsiella Staphylococcus Newcastle Disease
Leptospira Streptococcus Rabies

*FMDV is effectively eliminated with the pH buffered product F10CL General Farm Disinfectant

APPLICATIONS

The core product F1OCL VETERINARY DISINFECTANT is a high performance surface acting biocidel compound and due to its inherently low toxicity and low irritation characteristics is widely used within the veterinary profession in companion and large animal practices, referral hospitals, zoo’s, laboratories, and various other institutions. It is used in numerous applications, i.e. cold sterilisation of instruments and equipment including endoscopes, intravenous catheters, and endotracheal tubes; high level disinfection of hard surfaces and air spaces, water treatment, and as a sanitising rinse for solid food and fruit. Fogging with F10 CL VETERINARY DISINFECTANT, (a spray of fine mist-like droplets) has been shown to be 100% effective in eliminating airborne micro­organisms.

F10 DISINFECTANT (and under the label F10 ANTISEPTIC SOLUTION is authorised by the VMD* and FDA**) for use in aerosol fogging applications in the presence of animals as well as a number of clinical applications including nebulising in respiratory tract Aspergillosis infections, wound irrigation, and nasal flushing. *VMD Schedule 6,SAES , **FDA MU MS Index.

F10 DISINFECTANT RTU is a 1:50 pre-diluted solution of F1OCL Veterinary Disinfectant for HLD (high level disinfection).

F1OCLXD VETERINARY DISINFECTANT/CLEANSER is used for hard surface disinfection and cleaning of lightly soiled areas such as kennels and cages.

F10 SKIN PREP SOLUTION is a pre-op skin decontaminant.

F10 ODOUR ELIMINATOR is a hard surface and aerosol high level disinfectant with a masking pine fragrance.

F10 AEROSOL DISINFECTANT is available with on/off and total evacuation actuators for use as a hard surface and air space disinfectant. Tests have shown that aerosol disinfection is an effective method of carrying out high level disinfection of air spaces.

F10 INSECTICIDE SURFACE SPRAY FOR ANIMAL HOUSING is a hard surface disinfectant for animal housing, effective against flying and crawling insects such as blow flies, biting flies, fleas, midges, mites, mosquitoes and ticks.

F10 WIPES are a disinfectant impregnated surface wipe for use on equipment such as thermometers, and for hand decontamination when washing facilities are unavailable.

ANTIMICROBIALACTION

The antimicrobial action mechanism of the F10 branded disinfectants is taken from each component separately but in addition is due to the additive synergistic action of all components combined.

Bactericidal tests have been carried out in accordance with SANS 636-2001 – Standard (South African) having a performance pass criteria of >log’ reduction in microbial counts, the AFNOR Standard (French) which is a >log’ reduction in microbial counts, the European Union EN Standard which is a >Iog° reduction in microbial counts, and the AOAC Standard (USA) which is a >log° (1,000,000 times) reduction in microbial counts. MIC in-vitro tests have shown significant depth of performance as indicated. Generally testing was carried out at ambient temperatures with the exception of EN Standard tests where some were carried out at low temperatures 10°C. The EN Standard for low temperatures is 10°C and at this temperatures bactericidal performance was equal to that at ambient temperatures. Other tests carried out at elevated temperatures of 45°C showed a significant increase in performance.

FIGURE A: THE F10CL MIC VALUES

Test organism Concentration of F1OCL (dilution) that resulted in complete
visual inhibition of the Test organism = MIC value
Pseudomonas aeruginosa -ATCC 27853 A dilution of 1/200 or 0,5 % F1OCL
Escherichia coli – ATCC 25922 A dilution of 1/800 or 0,125 % F1OCL
Staphylococcus aureus -ATCC 25923 A dilution of 1/3200 or 0,03125 % F1OCL
Klebsiella pneumoniae – ATCC 10031 A dilution of 1/800 or 0,125 % F1OCL
Staphylococcus aureus – MRSA Local isolate A dilution of 1/3200 or 0,03125 % F1OCL
Pasteurella multocida – Local isolate A dilution of 1/3200 or 0,03125 % F1OCL
Enterococcus faecalis – ATCC 29212 A dilution of 1/3200 or 0,03125 % F1OCL
Salmonella choleraesuis, Serotype typhimurium – ATCC 13311 A dilution of 1/1600 or 0,0625 % F1OCL

Fungicidal tests have been carried out in accordance with SANS 636-2001, AFNOR and EN Standards which require a log3 and log4 reduction in microbial counts respectively.

Virucidal tests have been carried out in accordance with various internationally accepted protocols by the UP Faculty of Veterinary Science’s Department of Poultry Diseases, and the Department of Veterinary Tropical Diseases; theARC – Onderstepoort Veterinary Institute. The FMDV test was carried in accordance with the DEFRA (UK) Standard (F1OCL General Farm Disinfectant only). Test requirements called for log’and logs reduction in microbial counts.

Sporicidal tests have been carried out in accordance with EN 13704-2002, 13697-2001, and 1650-1997 Standards which required a log5 reduction in microbial counts.

CONCENTRATIONS AND CONTACT TIMES

Concentrations and contact times are indicated on each product label. It should be noted that additional tests were carried out to determine various speed of kill rates to meet varying application demands.

Bactericidal test standard contact times are generally 5 minutes. However it was found that a log3 reduction in gram positive bacteria was achieved in 30 seconds and similarly 60 seconds for gram negative bacteria all at a concentration of 1:100 of the F10 CL Veterinary Disinfectant. In the AOAC test a log6 reduction was achieved in both gram positive and gram negative bacteria in a 10 minutes contact time.

Fungi in the vegetative state, yeasts and moulds were eliminated in 30 seconds at a concentration of 1:100 of Fl OCL Veterinary Disinfectant.

Enveloped viruses were inactivated at 1:100 in 10 minutes whereas the more resistant non-enveloped viruses required a concentration of up to 1:20 with a contact time of 10 minutes to achieve the same reduction.

Bacterial and fungal spores log5 reduction could be achieved in 5 minutes at a concentration of 1:20 or using 1:50 in 15 minutes with F1OCL Veterinary Disinfectant.

DOSAGE AND DIRECTIONS FOR USE

For F10 CL VETERINARY DISINFECTANTS clear away debris and rinse surfaces, then apply as below:

  • Environmental general disinfection dilute 1:100
  • High level disinfection (including fungal spores) dilute 1:50
  • Resistant viruses (e.g. parvovirus) dilute 1:25
  • Sterilisation of instruments/equipment dilute 1:20

Additional information is available in application user guidelines. Other products refer to each specific product label.

TOXICICOLOGY OF F10 CL DISINFECTANT AT HIGHEST AS USED CONCENTRATION
Studies were carried out by a GLP laboratory in accordance with OECD and EPA guidelines.

Information on toxicological effects

 
Toxicity USE DILUTIONS (1:20 and higher)
Acute Oral Toxicity: (Rat) No toxicity
Acute Dermal Toxicity: (Rat) No toxicity
Acute Eye Irritation None
Acute Dermal Irritation None
Acute Inhalation Toxicity None
Skin Sensitization Not a skin sensitizer
Carcinogenicity, mutagenicity and
toxicity for reproduction
Based on data for the raw materials, no carcinogenic, mutagenic or toxicity for reproduction is predicted

Ecological information

 
Aquatic Toxicity Fish Not available
Aquatic Toxicity Algae Not available
Aquatic Toxicity Daphnia Not available

Residual toxicity

Five-week supervised trial using day-old broiler chicks restricted to 1:200 and 1:50 solutions of F1OCL in drinking water showed no F10 residual build-up in muscle meat, liver or kidneys.

PERSISTENCE AND DEGRADABILITY

For practical purpose the in-use product is biodegradable.

BIOACCUMULATIVE POTENTIAL

No known adverse effects from normal use.

MOBILITY IN SOIL Immobile in soil.

CORROSION

The F10 Veterinary Disinfectants are non-corrosive.at the recommended dilutions (complies with SABS test 1615 on polished aluminium strip after 30 days).

FREE RINSING

All F1OCL Veterinary Disinfectants are free rinsing at recommended dilutions (complies with SABS test 1593 6.11).

WATER INSOLUBLE MATTER CONTENT

The water insoluble matter content of F1OCL Veterinary Disinfectants and F10 Skin Prep Solution is 0,3g/litre (complies with SABS 1593 6.12).

PRECAUTIONSAND WARNINGS —see product labels

REGISTRATION HOLDER

Health and Hygiene (Pty) Ltd. PO Box 906, Florida Hills, 1716, South Africa.

MANUFACTURED BY

Health and Hygiene (Pty) Ltd in accordance with GMP (Good Manufacturing Practice) license reference M-7586 issued byAPVMAand SABS 636 Permit 6656/9863.

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